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Study identifier: NCT05185505 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Atezolizumab and Bevacizumab Pre-Liver Transplantation for Patients With Hepatocellular Carcinoma Beyond Milan Criteria

Condition: Hepatocellular Carcinoma · Hepatocellular Cancer  ·  Sponsor: The Methodist Hospital Research Institute

PhasePhase 4
Planned participants24
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Patients with hepatocellular carcinoma (HCC) beyond Milan Criteria (MC) who are transplant-eligible will be treated with 6 months of neoadjuvant/downstaging atezolizumab plus bevacizumab while receiving standard of care transarterial chemoembolization (TACE). We hypothesize that atezolizumab and bevacizumab can appropriately bridge patients with HCC beyond MC to transplantation and not increase the risk of 1-year post-transplant rejection.

This description comes directly from the study's public registry record.

Talk to the study team

Darrel Cleere, BSN  ·  713-441-6232  ·  dwcleere@houstonmethodist.org

Shondra Word  ·  713-441-5122  ·  sword@houstonmethodist.org

Always discuss trial participation with your own doctor first.

Locations (1)

Houston Methodist Research InstituteHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05185505