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Study identifier: NCT05176483 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

Condition: Renal Cell Carcinoma (RCC) · Metastatic Castration-Resistant Prostate Cancer (mCRPC) · Urothelial Carcinoma (UC)  ·  Sponsor: Exelixis

PhasePhase 1
Planned participants1314
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a multicenter Phase 1b, open label, dose-escalation and cohort-expansion study, evaluating the safety, tolerability, pharmacokinetics (PK), preliminary antitumor activity, and effect of biomarkers of zanzalintinib administered alone, and in combination with nivolumab (doublet), nivolumab + ipilimumab (triplet) and nivolumab + relatlimab (triplet) in participants with advanced solid tumors. In the Expansion Stage, the safety and efficacy of zanzalintinib as monotherapy and in combination therapy will be further evaluated in tumor-specific Expansion Cohorts.

This description comes directly from the study's public registry record.

Talk to the study team

Exelixis Clinical Trials  ·  1-888-EXELIXIS (888-393-5494)  ·  druginfo@exelixis.com

Backup or International  ·  650-837-7400

Always discuss trial participation with your own doctor first.

Locations (122)

Exelixis Clinical Site #67Phoenix, Arizona, United StatesRecruiting
Exelixis Clinical Site #1Tucson, Arizona, United StatesRecruiting
Exelixis Clinical Site #123Palo Alto, California, United StatesRecruiting
Exelixis Clinical Site #59Santa Barbara, California, United StatesRecruiting
Exelixis Clinical Site #87Littleton, Colorado, United StatesRecruiting
Exelixis Clinical Site #62New Haven, Connecticut, United StatesRecruiting
Exelixis Clinical Site #49Newark, Delaware, United StatesActive Not Recruiting
Exelixis Clinical Site #48Celebration, Florida, United StatesRecruiting
Exelixis Clinical Site #11Gainesville, Florida, United StatesRecruiting
Exelixis Clinical Site #78Jacksonville, Florida, United StatesRecruiting
Exelixis Clinical Site #47Miami, Florida, United StatesRecruiting
Exelixis Clinical Site #61Plantation, Florida, United StatesRecruiting

+ 110 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05176483