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Study identifier: NCT05172973 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

Condition: Aortic Valve Insufficiency · Aortic Valve Stenosis  ·  Sponsor: Edwards Lifesciences

PhaseNA
Planned participants200
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4/X4S Transcatheter Heart Valve (THV) in subjects who are at high or greater risk with a failing aortic bioprosthetic valve.

This description comes directly from the study's public registry record.

Talk to the study team

Edwards THV Clinical Affairs  ·  949-250-2500  ·  THV_CT.gov@Edwards.com

Always discuss trial participation with your own doctor first.

Locations (36)

Hoag Memorial Hospital PresbyterianNewport Beach, California, United StatesRecruiting
Bay Area Structural Heart at Sutter HealthSan Francisco, California, United StatesRecruiting
Kaiser San FranciscoSan Francisco, California, United StatesRecruiting
Stanford University Medical CenterStanford, California, United StatesRecruiting
UC Health Medical Center of the RockiesLoveland, Colorado, United StatesRecruiting
Naples Community Hospital Healthcare SystemNaples, Florida, United StatesRecruiting
Emory University AtlantaAtlanta, Georgia, United StatesRecruiting
Piedmont Heart InstituteAtlanta, Georgia, United StatesRecruiting
Northwestern University ChicagoEvanston, Illinois, United StatesRecruiting
Alexian Brothers Hospital NetworkLisle, Illinois, United StatesRecruiting
Cardiovascular Research Institute of KansasWichita, Kansas, United StatesRecruiting
MedStar Union Memorial HospitalBaltimore, Maryland, United StatesRecruiting

+ 24 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05172973