Condition: Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Head and Neck Carcinoma of Unknown Primary · Sponsor: National Cancer Institute (NCI)
This phase I/Ib trial tests the safety and best dose of ipatasertib in combination with the usual treatment approach using chemotherapy together with radiation therapy ("chemo-radiation") in patients with head and neck cancer. Ipatasertib is in a class of medications called protein kinase B (AKT) inhibitors. It may stop the growth of tumor cells and may kill them. Cisplatin, which is a chemotherapy used in this trial, is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of cancer cells. Radiation therapy uses high energy to kill tumor cells and shrink tumors. Giving ipatasertib in combination with chemo-radiation may be better than chemo-radiation alone in treating patients with advanced head and neck cancer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Moffitt Cancer Center | Tampa, Florida, United States | Recruiting |
| Northwestern University | Chicago, Illinois, United States | Recruiting |
| University of Kansas Clinical Research Center | Fairway, Kansas, United States | Recruiting |
| University of Kansas Cancer Center | Kansas City, Kansas, United States | Recruiting |
| University of Kansas Hospital-Westwood Cancer Center | Westwood, Kansas, United States | Recruiting |
| University of Kentucky/Markey Cancer Center | Lexington, Kentucky, United States | Active Not Recruiting |
| University of Maryland/Greenebaum Cancer Center | Baltimore, Maryland, United States | Recruiting |
| Rutgers Cancer Institute of New Jersey | New Brunswick, New Jersey, United States | Recruiting |
| Rutgers New Jersey Medical School | Newark, New Jersey, United States | Recruiting |
| Montefiore Medical Center-Einstein Campus | The Bronx, New York, United States | Recruiting |
| Montefiore Medical Center - Moses Campus | The Bronx, New York, United States | Recruiting |
| Carolinas Medical Center/Levine Cancer Institute | Charlotte, North Carolina, United States | Active Not Recruiting |
+ 6 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05172245