Condition: Locally Advanced Hepatocellular Carcinoma · Metastatic Hepatocellular Carcinoma · Stage III Hepatocellular Carcinoma AJCC v8 · Sponsor: Academic and Community Cancer Research United
This phase II trial tests whether atezolizumab in combination with a multi-kinase inhibitor (cabozantinib or lenvatinib) compared to multi-kinase inhibitor alone in treating patients with liver cancer that cannot be removed by surgery (unresectable), has spread to has spread to nearby tissue or lymph nodes (locally advanced), or has spread to other places in the body (metastatic), for which the patient has received treatment in the past (previously treated). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cabozantinib and lenvatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving atezolizumab with cabozantinib or lenvatinib may kill more tumor cells in patients with liver cancer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Mayo Clinic in Arizona | Scottsdale, Arizona, United States | Recruiting |
| Mayo Clinic in Florida | Jacksonville, Florida, United States | Withdrawn |
| Cleveland Clinic Weston Florida | Weston, Florida, United States | Withdrawn |
| University of Chicago Comprehensive Cancer Center | Chicago, Illinois, United States | Not Yet Recruiting |
| Carle Cancer Center NCI Community Oncology Research Program | Urbana, Illinois, United States | Recruiting |
| University Medical Center New Orleans | New Orleans, Louisiana, United States | Recruiting |
| Michigan Cancer Research Consortium NCORP | Ann Arbor, Michigan, United States | Recruiting |
| University of Michigan Comprehensive Cancer Center | Ann Arbor, Michigan, United States | Not Yet Recruiting |
| Mayo Clinic in Rochester | Rochester, Minnesota, United States | Recruiting |
| Roswell Park Cancer Institute | Buffalo, New York, United States | Recruiting |
| Duke University Medical Center | Durham, North Carolina, United States | Completed |
| University Hospitals Cleveland Medical Center | Cleveland, Ohio, United States | Withdrawn |
+ 4 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05168163