Condition: Sinusitis, Chronic · Sinus Infection Chronic · Sponsor: Centre Hospitalier Intercommunal Creteil
Purulent Oedematous Sinusitis (POS) is a particular form of chronic rhinosinusitis observed in 2% of the general population. In spite of its heavy impact on the quality of life, There is no established recommendation for the treatment of primary POS. Long-term low-dose macrolides are currently proposed for these forms of chronic rhinosinusitis when conventional treatments (local corticosteroids, saline rinsing, iterative short courses of antibiotics targeted on pathogens, and surgical opening and drainage) have failed. This treatment with macrolides is currently applied off-label. This study aims to assess the efficacy of macrolides in POS. An extensive workup is fulfilled to exclude other forms of chronic rhinosinusitis (Th2 biased inflammatory diseases, allergic diseases) (allergy, nasosinusal polyposis) or those due to cystic fibrosis or immune deficiency.
This description comes directly from the study's public registry record.
Emilie BEQUIGNON · 0145175000 · emilie.bequignon@chicreteil.fr
Camille JUNG · 0145175000 · camille.jung@chicreteil.fr
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| CHU Bordeaux | Bordeaux, France | Not Yet Recruiting |
| Hôpital Henri Mondor | Créteil, France | Recruiting |
| CHU Bicêtre, AP-HP | Le Kremlin-Bicêtre, France | Recruiting |
| CHU Lille | Lille, France | Recruiting |
| CHU de la Croix Rousse | Lyon, France | Recruiting |
| Hospices de Lyon | Lyon, France | Recruiting |
| Hôpitaux Universitaires de Marseille Conception | Marseille, France | Recruiting |
| CHRU de Nancy | Nancy, France | Recruiting |
| Centre Hospitalier Universitaire De Nantes | Nantes, France | Recruiting |
| Hôpital Lariboisiere | Paris, France | Recruiting |
| CHU Cochin | Paris, France | Not Yet Recruiting |
| CHU Toulouse | Toulouse, France | Not Yet Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05157685