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Study identifier: NCT05156983 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of TAK-330 to Reverse the Effects of Factor Xa Inhibitors For Adults Needing Urgent Surgery

Condition: Coagulation Disorder  ·  Sponsor: Takeda

PhasePhase 3
Planned participants440
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The aim of this study is to find out the effects of TAK-330 compared with four-factor prothrombin complex concentrate (4F-PCC) as part of standard treatment other than Prothromplex Total for anticoagulation reversal in participants treated with Factor Xa inhibitors who require urgent surgery/invasive procedure. The participant will be assigned by chance to either TAK-330 or SOC 4F-PCC as part of standard treatment before surgery. Patients participating in this study will need to be hospitalized. They will also be contacted (via telehealth/phone call) 30 days after the surgery.

This description comes directly from the study's public registry record.

Talk to the study team

Takeda Contact  ·  +1-877-825-3327  ·  medinfoUS@takeda.com

Always discuss trial participation with your own doctor first.

Locations (64)

University of Arkansas Medical SciencesArkansas City, Arkansas, United StatesRecruiting
University of California Davis Health SystemSacramento, California, United StatesRecruiting
Denver Metro Orthopedics, P.C.Englewood, Colorado, United StatesRecruiting
University of FloridaGainesville, Florida, United StatesRecruiting
Rutgers, The State University of New JerseyNew Brunswick, New Jersey, United StatesRecruiting
ECU Health Medical CenterGreenville, North Carolina, United StatesRecruiting
Metro Health Medical CenterCleveland, Ohio, United StatesRecruiting
Ohio State UniversityColumbus, Ohio, United StatesRecruiting
Ascension St. John Medical CenterTulsa, Oklahoma, United StatesRecruiting
University of Pennsylvania - Perelman School of MedicinePhiladelphia, Pennsylvania, United StatesRecruiting
UPMCPittsburgh, Pennsylvania, United StatesRecruiting
University of Texas Southwestern Medical CenterDallas, Texas, United StatesRecruiting

+ 52 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05156983