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Study identifier: NCT05150691 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors

Condition: HER2-positive Advanced Solid Tumor  ·  Sponsor: DualityBio Inc.

PhasePhase 1/Phase 2
Planned participants796
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced solid tumors that express HER2.

This description comes directly from the study's public registry record.

Talk to the study team

Britney Winterberger  ·  +1-513-403-8568  ·  britney.winterberger@tigermedgrp.com

Always discuss trial participation with your own doctor first.

Locations (102)

Helios Clinical ResearchCerritos, California, United StatesActive Not Recruiting
California Research InstituteLos Angeles, California, United StatesActive Not Recruiting
Sharp Memorial HospitalSan Diego, California, United StatesActive Not Recruiting
Washington Cancer Institute at MedStar Washington Hospital CenterWashington D.C., District of Columbia, United StatesActive Not Recruiting
Advanced Research LLCCoral Springs, Florida, United StatesActive Not Recruiting
The Oncology Institute of Hope and InnovationLakeland, Florida, United StatesActive Not Recruiting
D&H Cancer Research Center LLCMargate, Florida, United StatesActive Not Recruiting
HCA Mercy HospitalMiami, Florida, United StatesWithdrawn
BRCR Medical Center Inc.Plantation, Florida, United StatesActive Not Recruiting
BRCR Medical Center Inc.Tamarac, Florida, United StatesActive Not Recruiting
Southeastern Regional Medical Center, LLCNewnan, Georgia, United StatesActive Not Recruiting
Kapi'olani Medical Center for Women and ChildrenHonolulu, Hawaii, United StatesActive Not Recruiting

+ 90 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05150691