Condition: Contrast-induced Acute Kidney Injury (CI-AKI) Following Coronary Angiogram (CI-AKI) · Contrast-induced Nephropathy Following Coronary Angiogram (CIN) · Sponsor: The University of Texas Medical Branch, Galveston
The use of imaging is increasing in clinical practice, either for diagnosis or intervention. In these imaging processes, contrast medium (CM) is widely used. However, CM administration can induce contrast-induced nephropathy (CI-AKI). CI-AKI is the third most common cause of renal insufficiency, and its incidence varies from 2% to 50% depending on patient risk factors; in addition, studies have shown that CI-AKI occurs in 2% to 25% of patients undergoing coronary intervention. CI-AKI is associated with significant mortality and morbidity in patients undergoing coronary angiography or other diagnostic contrast studies. We assessed the latest promising evidence on the ability of remote ischemic preconditioning (RIPC) to reduce the incidence of CI-AKI in patients undergoing Coronary Angiogram (CA) or diagnostic contrast studies such as CT angiogram, while at the same time being a non-invasive, low cost, easy, and safe method with absence of adverse effects. However, more randomized controlled trials are needed to confirm these preliminary results. The aim of this study is to minimize the incidence of CI-AKI at the University of Texas Medical Branch (UTMB). If found to be an effective method, RIPC would help minimize the incidence of CI-AKI in all institutions across the globe, who would adopt this intervention. The primary objective: i) reduce the rise in creatinine to \< 0.5 mg/dL post-CA in moderate to high risk patients and ii) reduce the incidence of renal replacement ther…
This description comes directly from the study's public registry record.
Salman Salehin, MD · +12818189321 · sasalehi@utmb.edu
Khaled Chatila, MD · +14436005821 · kfchatil@utmb.edu
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| University of Texas- Medical Branch (UTMB) | Galveston, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05147831