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Study identifier: NCT05145764 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Suvorexant as an Adjunct to Buprenorphine in Persons Who Use Fentanyl

Condition: Suvorexant · Placebo · Opioid Use Disorder  ·  Sponsor: Johns Hopkins University

PhasePhase 2
Planned participants120
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

This is a 4-week, randomized-controlled trial of suvorexant vs placebo in persons with opioid use disorder who have recent fentanyl exposure. Participants will first undergo a 5-day residential phase wherein participants are stabilized on sublingual buprenorphine/naloxone, followed by a 3-week outpatient phase wherein participants are maintained on sublingual buprenorphine/naloxone and transitioned to extended-release buprenorphine).

This description comes directly from the study's public registry record.

Talk to the study team

Andrew S Huhn, Ph.D.  ·  410-550-1971  ·  ahuhn1@jhu.edu

Kelly E Dunn, Ph.D.  ·  410-550-2254  ·  kdunn9@jhmi.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Johns Hopkins Bayview Medical CenterBaltimore, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05145764