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Study identifier: NCT05138575 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial

Condition: Heart Failure With Preserved Ejection Fraction  ·  Sponsor: University of Pennsylvania

PhasePhase 2
Planned participants53
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will test whether pharmacologic agents that may improve mitochondrial function and energy fuel metabolism \[Empagliflozin (Empa)\], with and without additional supplements that increase perfusion and fatty acid oxidation \[Potassium Nitrate (KNO3)\], improve submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF).

This description comes directly from the study's public registry record.

Talk to the study team

Melissa Fernando  ·  2672536141  ·  fernand@Pennmedicine.upenn.edu

Cassandra Demastus, CRNP  ·  Cassandra.Demastus@Pennmedicine.upenn.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Pennsylvania Health SystemPhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05138575