Condition: Clinical Stage III Cutaneous Melanoma AJCC v8 · Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Clinical Stage IV Cutaneous Melanoma AJCC v8 · Sponsor: National Cancer Institute (NCI)
This phase II trial studies the good and bad effects of the combination of drugs called cabozantinib and nivolumab in treating patients with melanoma or squamous cell head and neck cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial may help doctors determine how quickly patients can be divided into groups based on biomarkers in their tumors. A biomarker is a biological molecule found in the blood, other body fluids, or in tissues that is a sign of a normal or abnormal process or a sign of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. The two biomarkers that this trial is studying are "tumor mutational burden" and "tumor inflammation signature." Another purpose of this trial is to help doctors learn if cabozantinib and nivolumab shrink or stabilize the cancer, and whether patients respond differently to the combination depending on the status of the biomarkers.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Mayo Clinic Hospital in Arizona | Phoenix, Arizona, United States | Recruiting |
| University of Arkansas for Medical Sciences | Little Rock, Arkansas, United States | Recruiting |
| Tower Cancer Research Foundation | Beverly Hills, California, United States | Recruiting |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine, California, United States | Recruiting |
| The Angeles Clinic and Research Institute - West Los Angeles Office | Los Angeles, California, United States | Recruiting |
| Cedars-Sinai Medical Center | Los Angeles, California, United States | Recruiting |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange, California, United States | Recruiting |
| Rocky Mountain Regional VA Medical Center | Aurora, Colorado, United States | Active Not Recruiting |
| UCHealth Memorial Hospital Central | Colorado Springs, Colorado, United States | Recruiting |
| Memorial Hospital North | Colorado Springs, Colorado, United States | Recruiting |
| Poudre Valley Hospital | Fort Collins, Colorado, United States | Recruiting |
| Cancer Care and Hematology-Fort Collins | Fort Collins, Colorado, United States | Recruiting |
+ 213 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05136196