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Study identifier: NCT05133843 Synced from ClinicalTrials.gov · July 29, 2026
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Complete Functional Assessment of Intermediate Coronary Artery Stenosis Before and After Transcatheter Aortic Valve Implantation (TAVI) in Patients With Severe Symptomatic Aortic Valve Stenosis

Condition: Coronary Artery Stenosis · Transcatheter Aortic Valve Implantation  ·  Sponsor: Helios Health Institute GmbH

PhaseNA
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of the current study is to assess complete coronary physiology (FFR, RFR, CFR, IMR, and CT-FFR) in TAVI candidates with intermediate coronary artery stenosis before and 6 months after TAVI. This aims to determine how TAVI affects coronary blood flow and coronary microcirculatory function after longer-term follow-up, and how these effects influence FFR and RFR values. In addition, it is aimed to correlate invasive functional testing (FFR and RFR) with non-invasive CT-FFR before and 6 months after TAVI.

This description comes directly from the study's public registry record.

Talk to the study team

Nicolas Majunke, Dr.  ·  +49 341 865 1428  ·  nicolas.majunke@medizin.uni-leipzig.de

Mohamed Abdel-Wahab, Prof. Dr.

Always discuss trial participation with your own doctor first.

Locations (1)

Heart Center Leipzig at University of Leipzig Department of Internal Medicine/CardiologyLeipzig, GermanyRecruiting

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Source record: clinicaltrials.gov/study/NCT05133843