← Eichor
Study identifier: NCT05131321 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

FRAME Study (Frailty-Related Ankle Fracture Management and Evaluation)

Condition: Ankle Fractures · Pilon Fracture  ·  Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

PhaseN/A
Planned participants172
Who can joinAll sexes, 40 Years to no upper limit
Healthy volunteersNo

About this study

This will be a multi-centre randomized controlled trial, with London Health Sciences Centre (LHSC) as the lead site. Elderly patients with complex ankle fractures who meet the inclusion criteria and provide consent will be randomized (through a web-based randomization system) to one of the two treatment arms. One group (Group A) will receive primary ankle fusion, and the second group (Group B) will receive primary ankle open reduction and internal fixation (ORIF). Patient important outcomes will be compared at one year post injury The Investigators have amended the study to include a second part for patients with less complicated but still unstable ankle fractures. In this part, patients will be randomly assigned to receive either a procedure called ORIF or another one called retrograde intramedullary fibular nailing.

This description comes directly from the study's public registry record.

Talk to the study team

Emil Schemitsch, MD, FRCS(C)  ·  519-663-3307  ·  emil.schemitsch@lhsc.on.ca

Abdel Lawendy, MD, FRCS(C)  ·  519-685-8500  ·  AbdelRahman.Lawendy@lhsc.on.ca

Always discuss trial participation with your own doctor first.

Locations (1)

London Health Sciences CentreLondon, Ontario, CanadaRecruiting

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT05131321