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Study identifier: NCT05130801 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of Multiparametric MRI and pHLIP® ICG in Breast Cancer Imaging During Surgery

Condition: Breast Cancer  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 1/Phase 2
Planned participants55
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to find out whether pre-operative mpMRI using additional MRI sequences may improve surgical outcomes by providing more accurate information about the extent and acidity of the tumor than standard MRI, and to see whether the use of the fluorescent imaging agent pHLIP ICG and NIRF imaging during surgery is a safe approach that may allow the surgeon to see the tumor and nearby tissues that contain cancer cells more clearly and remove them completely. During the Phase IIa part of this study, the safe dose of pHLIP ICG will be used that makes it easy for the surgeon to see the tumor and the nearby tissues and structures that may contain cancer cells. This study is the first to test pHLIP ICG in people, and the first to test the use of pHLIP ICG with mpMRI and NIRF imaging in surgery for breast cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Clarissa Lin, MD  ·  646-888-5119  ·  linc5@mskcc.org

Monica Morrow, MD  ·  646-888-5350

Always discuss trial participation with your own doctor first.

Locations (2)

Memorial Sloan Kettering Bergen (All Protocol Activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05130801