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Study identifier: NCT05127434 Synced from ClinicalTrials.gov · July 28, 2026
● Completed

A Study to Evaluate the Safety and Efficacy of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in Adults ≥60 Years of Age

Condition: Respiratory Syncytial Virus  ·  Sponsor: ModernaTX, Inc.

PhasePhase 2/Phase 3
Planned participants36814
Who can joinAll sexes, 60 Years to no upper limit
Healthy volunteersYes

About this study

The main purpose of Part A of this study is to evaluate the safety and tolerability of mRNA-1345 vaccine and to demonstrate the efficacy of a single dose of mRNA-1345 vaccine in the prevention of a first episode of RSV-associated lower respiratory tract disease (RSV-LRTD) as compared with placebo from 14 days postinjection through 12 months. The main purpose of Part B of this study is to evaluate the safety, tolerability and immunogenicity of a booster dose (BD) of mRNA-1345 administered 24 months after the primary dose.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (269)

AES - DRS - Synexus Clinical Research US, Inc. - BirminghamBirmingham, Alabama, United States
Accel Research Site - Achieve - BirminghamBirmingham, Alabama, United States
Lakeview Clinical ResearchGuntersville, Alabama, United States
AES - DRS - Optimal Research Alabama - HuntsvilleHuntsville, Alabama, United States
Hope Research Institute LLC - Hunt - PPDSHunt, Arizona, United States
Hope Research Institute LLC - Hunt - PPDSHunt, Arizona, United States
Desert Clinical Research, LLC - CCTMesa, Arizona, United States
Hope Research Institute LLC - Phoenix - Hunt - PPDSPhoenix, Arizona, United States
AES - DRS - Synexus Clinical Research US, Inc. - Phoenix CentralPhoenix, Arizona, United States
Synexus Clinical Research US, Inc. - Phoenix SoutheastPhoenix, Arizona, United States
Tucson Neuroscience Research - M3 WRTucson, Arizona, United States
Baptist Health Center for Clinical ResearchLittle Rock, Arkansas, United States

+ 257 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05127434