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Study identifier: NCT05120635 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans

Condition: Fear · GAD · Emotional Memory  ·  Sponsor: Duke University

PhaseNA
Planned participants80
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersYes

About this study

Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. The purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. These tasks will expose the participants to various levels of fear-provoking images. Participants with responsive neurostimulation (RNS) implants will be enrolled under Pro00117931 at Duke, but their results for fear and anxiety tasks will be reported under NCT05120635.

This description comes directly from the study's public registry record.

Talk to the study team

Gabriela Vilchez  ·  9196812577  ·  suthanalab@duke.edu

Always discuss trial participation with your own doctor first.

Locations (2)

University of California Los AngelesLos Angeles, California, United StatesRecruiting
Duke University Health SystemDurham, North Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05120635