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Study identifier: NCT05116384 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Renal Denervation + PVI vs PVI Alone for Persistent AF

Condition: Atrial Fibrillation  ·  Sponsor: University of Rochester

PhaseNA
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Pulmonary vein isolation (PVI) is the cornerstone of ablation for atrial fibrillation (AF). Increased cardiac sympathetic stimulation can facilitate AF and reduction can be accomplished by renal artery denervation (RDN). The recently completed randomized trial, ERADICATE-AF, convincingly demonstrated that RDN plus PVI resulted in a reduction in recurrent incident AF for uncontrolled hypertensives. This is a randomized controlled pilot trial, "To Evaluate Renal Artery Denervation in Addition to Catheter Ablation to Eliminate Atrial Fibrillation" (ERADICATE-AF II) to test if RDN plus PVI enhances long-term efficacy vs PVI for persistent AF patients with controlled or without hypertension using implantable loop recordings.

This description comes directly from the study's public registry record.

Talk to the study team

Jonathan Steinberg, MD  ·  9734364155  ·  jsteinberg@smgnj.com

Always discuss trial participation with your own doctor first.

Locations (1)

University of RochesterShort Hills, New Jersey, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05116384