Condition: Atrial Fibrillation · Heart Failure · Sponsor: Shanghai 10th People's Hospital
One-stop procedure combining catheter ablation (CA) and left atrial appendage closure (LAAC) has been a feasible treatment for patients with atrial fibrillation at high risk of stroke and/or bleeding. Although it could achieve considerable rhythm control and stroke prophylaxis, a number of patients has experienced progressive heart failure after the procedure. Notably, previous studies indicate that both pulmonary vein isolation by CA and LAAC could significantly increase left atrial pressure, while currently no study has investigated left atrial pressure change in patients underwent combined procedure. The investigators hypothesise that combined procedure would significantly increase left atrial pressure and subsequently deteriorate cardiac function. Therefore, the investigators aim to measure the left and right atrial pressure change before and after CA and LAAC in combined procedure, and investigate the influence of the pressure change on clinical outcomes.
This description comes directly from the study's public registry record.
Dongdong Zhao · +86 18917684008 · zhaodd@tongji.edu.cn
Zhongyuan Ren · +86 18862186450 · 2111714@tongji.edu.cn
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| Department of Cardiology, Shanghai Tenth People's Hospital | Shanghai, Shanghai Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05106270