Condition: Basilar Artery Occlusion · Sponsor: University of Melbourne
Patients presenting to the emergency department with an acute ischemic stroke due to basilar artery occlusion within 24 hours of stroke onset will be assessed to determine their eligibility for randomization into the trial. If the patient gives informed consent they will be randomised 50:50 using a central computerised allocation process to either standard of care (no intravenous thrombolytic treatment or intravenous alteplase 0.9mg/kg) or tenecteplase 0.25mg/kg before undergoing mechanical thrombectomy as required at treating clinician's discretion. The trial is Multi-arm, Multi-stage, prospective, randomised, open-label, blinded endpoint (PROBE) design with seamless phase 2b/3 transition if the intermediate endpoint (recanalization without symptomatic intracerebral hemorrhage) is met in analysis of the first 202 patients. Adaptive sample size re-estimation (Mehta and Pocock) will be performed when 240 patients have completed 3 month follow-up (minimum sample size 320, maximum sample size 688).
This description comes directly from the study's public registry record.
Fana Alemseged, MD, PhD · +6193424424 · Fana.Alemseged@unimelb.edu.au
Erin White · erin.white@florey.edu.au
Always discuss trial participation with your own doctor first.
| Bankstown-Lidcombe Hospital | Bankstown, New South Wales, Australia | Not Yet Recruiting |
| John Hunter Hospital | Newcastle, New South Wales, Australia | Not Yet Recruiting |
| Liverpool Hospital | Sydney, New South Wales, Australia | Recruiting |
| Gold Coast Hospital | Gold Coast, Queensland, Australia | Not Yet Recruiting |
| Princess Alexandra Hospital | Woolloongabba, Queensland, Australia | Recruiting |
| Royal Adelaide Hospital | Adelaide, South Australia, Australia | Recruiting |
| Alfred Health | Melbourne, Victoria, Australia | Recruiting |
| Austin Hospital | Melbourne, Victoria, Australia | Recruiting |
| Box Hill Hospital | Melbourne, Victoria, Australia | Recruiting |
| Monash Health | Melbourne, Victoria, Australia | Not Yet Recruiting |
| Royal Melbourne Hospital | Melbourne, Victoria, Australia | Recruiting |
| Western Health | Melbourne, Victoria, Australia | Recruiting |
+ 5 more locations — full list on the registry record.
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT05105633