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Study identifier: NCT05105152 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

PLAT-08: A Study Of SC-DARIC33 CAR T Cells In Pediatric And Young Adults With Relapsed Or Refractory CD33+ AML

Condition: Acute Myeloid Leukemia · Acute Myeloid Leukemia Refractory · Acute Myeloid Leukemia, in Relapse  ·  Sponsor: Seattle Children's Hospital

PhasePhase 1
Planned participants18
Who can joinAll sexes, N/A to 30 Years
Healthy volunteersNo

About this study

A phase 1, open-label, non-randomized study enrolling pediatric and young adult patients with relapsed or refractory CD33+ leukemia with and without prior history of allogeneic hematopoietic cell transplantation, to examine the safety and feasibility of administering an autologous T cell product that has been genetically modified to express a Dimerizing Agent Regulated Immunoreceptor Complex (DARIC).

This description comes directly from the study's public registry record.

Talk to the study team

Adam Lamble, MD  ·  206-986-2106  ·  CBDCIntake@seattlechildrens.org

Always discuss trial participation with your own doctor first.

Locations (1)

Seattle Children's HospitalSeattle, Washington, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05105152