Condition: Non Small Cell Lung Cancer · Pancreatic Cancer · Bladder Cancer · Sponsor: Origin Sciences
The aim of the study is to assess the feasibility of genomic and epigenetic analysis of rectal mucus to detect non-colorectal cancers of the aero- digestive tract using samples collected by the OriCol™ Sampling Device. The primary objective of the study is to assess whether significant changes in DNA mutation and methylation associated with Non-colorectal cancers of the Aero-digestive Tract (NCRCADT) can be detected in rectal mucus as shed cells and cell-free DNA (cfDNA) pass through the gut and theoretically can be collected from rectal mucus. Secondary objectives will assess the participant acceptability of the OriCol™ Sampling Device for Pancreatic Ductal Adenocarcinoma, Non-Small Cell Cancer of the Lung, Colorectal Cancer and Urological Cancer controls as well as contributing to a genomic library collating information about rectal mucus.
This description comes directly from the study's public registry record.
Ian Daniels, FRCS · 01223 750490 · Ian.Daniels@originsciences.com
Hugo Lywood · 01223750490 · hugo.lywood@originsciences.com
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| Royal Devon & Exeter NHS Foundation Trust | Exeter, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05102110