Condition: Advanced Gynecologic Tumors · Signal Switch Receptor Modified TIL · Treatment Side Effects · Sponsor: Shanghai Juncell Therapeutics
This study is to investigate the safety and efficacy of signal switch receptor modified TIL (GC201 TIL) in patients with advanced gynecologic tumors. Autologous TILs from tumor resections or biopsies are first gene modified(TGF-β receptor or PD-1 gene modified TILs which could transfer the suppression signal surrounding the microenvironment of tumor bed into persistent T cell activation signal) and than expanded before i.v. infusion into the patient after NMA lymphodepletion treatment with hydroxychloroquine(600mg,single-dose) and cyclophosphamide.
This description comes directly from the study's public registry record.
Clinical GC · 086-18001759113 · clinicaltrials@juncell.com
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| Shanghai Tenth People's Hospital | Shanghai, Shanghai Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05098171