Condition: Waldenstrom Macroglobulinemia · Sponsor: Fundación Española de Hematología y Hemoterapía
Waldenström's macroglobulinemia (WM) is a B-cell lymphoproliferative disorder which is defined by bone marrow infiltration by small lymphocytes, lymphoplasmacytoid and plasma cells together with the presence of a detectable monoclonal immunoglobulin M (IgM).The clinical presentation of WM is variable. Symptoms can be related to tumor infiltration, or they can be related to the monoclonal IgM component. The therapeutic options are heterogeneous and there are no well-established in both first line or relapse/refractory settings. In Spain, the incidence of MGUS-IgM and WM in the last decade is unknown. The aims of this retrospective, observational, multicentric study is: * To develop a national registry of patients diagnosed with Waldenström's Macroglobulinemia and Monoclonal Gammopathy of uncertain significance -IgM in Spain in the past 30years. * To evaluate the most relevant clinical characteristics, long-term safety and efficacy of different therapeutic schemes and long-term prognosis of patients with WM * To help in the design of future therapeutic strategies, risk prognostic factors and clinical trials in Spain. Methods: The investigators will collect data from the patient clinical files after prior Informed Consent providing from patients with diagnosis of MGUS-IgM and WM in the past 30 years in Spain, according to the WHO classification of lymphoid tumors (2008) revised in 2016. Data from patients not able to provide IC (i.e., already dead patients) will be included …
This description comes directly from the study's public registry record.
RAMON GARCIA SANZ, MD · +34 915868000 · rgarcias@usal.es
ELHAM ASKARI ASKARI, MD · +34 915504800 · easkari@fdj.es
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| Hospital de Mérida | Mérida, Badajoz, Spain | Recruiting |
| Hospital Son Llatzer | Palma, Balearic Islands, Spain | Recruiting |
| Hospital Universitario Son Espases | Palma de Mallorca, Balearic Islands, Spain | Recruiting |
| ICO Badalona - Hospital Germans Trias i Pujol | Badalona, Barcelona, Spain | Recruiting |
| Hospital Mutua Terrassa | Barcelona, Barcelona, Spain | Recruiting |
| Hospital de San Juan Despí Moisès Broggi | Barcelona, Barcelona, Spain | Recruiting |
| Hospital Clínic de Barcelona | Barcelona, Barcelona, Spain | Recruiting |
| Hospital del Mar | Barcelona, Barcelona, Spain | Recruiting |
| Hospital Vall d'Hebron | Barcelona, Barcelona, Spain | Recruiting |
| Hospital Sant Joan de Déu de Manresa | Manresa, Barcelona, Spain | Recruiting |
| Hospital Parc Taulí | Sabadell, Barcelona, Spain | Recruiting |
| Hospital Universitario Reina Sofía | Córdoba, Córdoba, Spain | Recruiting |
+ 39 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05093153