Condition: B-cell Acute Lymphoblastic Leukemia · Obesity · Sponsor: Etan Orgel
This study is for older children, adolescents, and young adults with B-cell Acute Lymphoblastic Leukemia (B-ALL). Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. Chemotherapy during the first month causes large gains in body fat in most people, even those who start chemotherapy at a healthy weight. This study is being done to find out if caloric restriction achieved by a personalized nutritional menu and exercise plan during routine chemotherapy can make the patient's ALL more sensitive to chemotherapy and also reduce the amount of body fat gained during treatment. The goals of this study are to help make chemotherapy more effective in treating the patient's leukemia as demonstrated by fewer patients with leukemia minimal residual disease (MRD) while also trying to reduce the amount of body fat that chemotherapy causes the patient to gain in the first month.
This description comes directly from the study's public registry record.
Ellynore Florendo · 323-361-3022 · eflorendo@chla.usc.edu
Roy Leong · 323-361-5132 · rleong@chla.usc.edu
Always discuss trial participation with your own doctor first.
| Children's Hospital Los Angeles | Los Angeles, California, United States | Recruiting |
| Children's Hospital Orange County | Orange, California, United States | Recruiting |
| UCSF School of Medicine | San Francisco, California, United States | Recruiting |
| Colorado Children's Hospital | Denver, Colorado, United States | Recruiting |
| Children's Healthcare of Atlanta at Egleston | Atlanta, Georgia, United States | Not Yet Recruiting |
| Ann & Robert H. Lurie Children's Hospital of Chicago | Chicago, Illinois, United States | Recruiting |
| Johns Hopkins / Sydney Kimmel Cancer Center | Baltimore, Maryland, United States | Not Yet Recruiting |
| C.S. Mott University of Michigan | Ann Arbor, Michigan, United States | Recruiting |
| Children's Hospitals and Clinics of Minnesota | Minneapolis, Minnesota, United States | Recruiting |
| Columbia University Medical Center | New York, New York, United States | Not Yet Recruiting |
| Levine Children's Hospital | Charlotte, North Carolina, United States | Recruiting |
| Cincinnati Children's Hospital Medical Center | Cincinnati, Ohio, United States | Not Yet Recruiting |
+ 8 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05082519