Condition: Acute Respiratory Distress Syndrome (ARDS) · Sponsor: Università Vita-Salute San Raffaele
Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury and a major cause of Intensive Care Unit (ICU) admission worldwide. Despite a large number of randomized clinical trials, a specific and effective pharmacological approach for patients with ARDS is still lacking. Fibroproliferation is a crucial part of the host defence response, and severe fibrotic lung disease affects ARDS patients even years after acute phase resolution. Pirfenidone is an oral anti-fibrotic drug, approved and largely used for treatment of idiopathic pulmonary fibrosis (IPF). The effect of Pirfenidone in ARDS has been evaluated only in animal models. This is a randomized controlled study to evaluate for the first time the efficacy of Pirfenidone in ARDS.
This description comes directly from the study's public registry record.
Nora Di Tomasso, MD · +39022643 · ditomasso.nora@hsr.it
Giacomo Monti, MD · +39022643 · monti.giacomo@hsr.it
Always discuss trial participation with your own doctor first.
| IRCCS San Raffaele Scientific Institute | Milan, MI, Italy | Recruiting |
| Ospedale Cesare Arrigo | Alessandria, Piedmont, Italy | Recruiting |
| Ospedale Santa Maria | Bari, Italy | Recruiting |
| ASST Spedali Civili di Brescia | Brescia, Italy | Recruiting |
| Ospedale San Giovanni di Dio - Azienda Ospedaliera Universitaria di Cagliari | Cagliari, Italy | Recruiting |
| Ospedale di Merano | Merano, Italy | Recruiting |
| Ospedale Uboldo di Cernusco sul Naviglio | Milan, Italy | Recruiting |
| Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico | Milan, Italy | Recruiting |
| AOU Policlinico Paolo Giaccone | Palermo, Italy | Recruiting |
| Azienda Ospedaliero Universitaria Pisana | Pisa, Italy | Recruiting |
| AOU Pisana | Pisa, Italy | Recruiting |
| A.O.R San Carlo | Potenza, Italy | Recruiting |
+ 5 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05075161