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Study identifier: NCT05068232 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Durvalumab and Ablative Radiation in Small Cell Lung Cancer (DARES)

Condition: Small-cell Lung Cancer · Extensive-stage Small-cell Lung Cancer · Lung Cancer  ·  Sponsor: University of Chicago

PhasePhase 2
Planned participants49
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This this study is for individuals who have treatment-naïve extensive-stage small cell lung cancer (small cell lung cancer that wont respond to treatment). Doctors leading this study hope to learn if combining durvalumab, carboplatin and etoposide with hyofractionated ablative radiation therapy (radiation focused on certain parts of the body) will help treat your cancer and improve how long you can live with extensive-stage small cell cancer without it getting worse (progression-free survival). Your participation in this research will last about 48 months. Durvalumab along with chemotherapy has been approved by the Food and Drug Administration (FDA) for the treatment of small cell lung cancer along with chemotherapy. This study is testing the addition of radiation to durvalumab and chemotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Cancer Clinical Trials Office  ·  1-855-702-8222  ·  cancerclinicaltrials@bsd.uchicago.edu

Aditya Juloori, MD  ·  PhaseIICRA@medicine.bsd.uchicago.edu

Always discuss trial participation with your own doctor first.

Locations (2)

University of Chicago MedicineChicago, Illinois, United StatesRecruiting
University of Wisconsin Carbone Cancer CenterMadison, Wisconsin, United StatesActive Not Recruiting

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Source record: clinicaltrials.gov/study/NCT05068232