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Study identifier: NCT05067283 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)

Condition: Advanced Solid Tumors  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 1
Planned participants830
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a study evaluating the safety, pharmacokinetics, and efficacy of calderasib alone, and calderasib plus other combination therapies in participants with advanced solid tumors with identified kirsten rat sarcoma viral oncogene homolog G12C (KRAS G12C) mutation.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (75)

Moffitt Cancer Center ( Site 0261)Tampa, Florida, United StatesRecruiting
START Midwest ( Site 0267)Grand Rapids, Michigan, United StatesRecruiting
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0260)Hackensack, New Jersey, United StatesRecruiting
Laura and Isaac Perlmutter Cancer Center ( Site 0270)New York, New York, United StatesCompleted
NEXT Virginia ( Site 0271)Fairfax, Virginia, United StatesRecruiting
MEDICAL COLLEGE OF WISCONSIN-Cancer Center Clinical Trials Office ( Site 0262)Milwaukee, Wisconsin, United StatesRecruiting
Instituto Alexander Fleming ( Site 0434)Ciudad Autónoma de Buenos Aires, Buenos Aires, ArgentinaRecruiting
Sanatorio Parque ( Site 0456)Rosario, Santa Fe Province, ArgentinaRecruiting
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0438)La Rioja, ArgentinaRecruiting
Chris O'Brien Lifehouse ( Site 0002)Camperdown, New South Wales, AustraliaRecruiting
Liverpool Hospital-Medical Oncology ( Site 0001)Liverpool, New South Wales, AustraliaRecruiting
Westmead Hospital ( Site 0006)Westmead, New South Wales, AustraliaRecruiting

+ 63 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05067283