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Study identifier: NCT05066217 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome

Condition: Lennox Gastaut Syndrome  ·  Sponsor: Epygenix

PhasePhase 3
Planned participants260
Who can joinAll sexes, 2 Years to 55 Years
Healthy volunteersNo

About this study

This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole HCL (EPX-100) as adjunctive therapy in children and adult participants with Lennox-Gastaut syndrome (LGS).

This description comes directly from the study's public registry record.

Talk to the study team

Juby Philip  ·  (302) 559-4320  ·  clinicaltrials@harmonybiosciences.com

Cindy Sandy  ·  (317) 258-7262  ·  clinicaltrials@harmonybiosciences.com

Always discuss trial participation with your own doctor first.

Locations (26)

Arkansas Children's HospitalLittle Rock, Arkansas, United StatesActive Not Recruiting
UC Irvine Medical CenterOrange, California, United StatesActive Not Recruiting
UCI Center for Innovative Health TherapiesOrange, California, United StatesRecruiting
Nemours Children's HealthWilmington, Delaware, United StatesNot Yet Recruiting
Rare Disease ResearchKissimmee, Florida, United StatesSuspended
University of Miami Miller School of MedicineMiami, Florida, United StatesRecruiting
AdventHealth Innovation TowerOrlando, Florida, United StatesRecruiting
Pediatric Neurology and Epilepsy SpecialistsWinter Park, Florida, United StatesActive Not Recruiting
Re:Cognition HealthChicago, Illinois, United StatesRecruiting
Norton Children's Medical CenterLouisville, Kentucky, United StatesActive Not Recruiting
Henry Ford HospitalDetroit, Michigan, United StatesActive Not Recruiting
Minnesota Epilepsy Group, P.A.Roseville, Minnesota, United StatesActive Not Recruiting

+ 14 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05066217