Condition: Acute Stroke · Ischemic Stroke · Stroke · Sponsor: DiaMedica Therapeutics Inc
This is a Phase 2/3 study evaluating the safety and efficacy of DM199 (rinvecalinase alfa) in treating participants with moderate stroke severity, who present within 24 hours of Acute Ischemic Stroke (AIS) onset due to small and medium vessel occlusions. This study focuses on participants with limited treatment options. Participants who have or will receive mechanical thrombectomy (MT) are not eligible for participation. Additionally, participants who have received fibrinolytics are excluded unless they experience a persistent neurological deficit of moderate severity six or more hours after fibrinolytic treatment. Participants considered for this trial should not be denied the use of standard of care (SoC) AIS therapies, such as fibrinolytics or MT, when appropriate. The double-blinded study will be randomized and placebo-controlled at up to approximately 100 sites.
This description comes directly from the study's public registry record.
Kayla Slupek · (717)304-7442 · kslupek@diamedica.com
Adrienne Ford · (717)658-6652 · aford@diamedica.com
Always discuss trial participation with your own doctor first.
| Gulf Health Hospitals d/b/a Thomas Hospital | Fairhope, Alabama, United States | Recruiting |
| USC Arcadia Hospital | Arcadia, California, United States | Recruiting |
| Glendale Adventist Medical Center d/b/a Adventist Health Glendale | Glendale, California, United States | Recruiting |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles, California, United States | Recruiting |
| Ronald Reagan UCLA Medical Center | Los Angeles, California, United States | Recruiting |
| Stanford Health Care | Stanford, California, United States | Recruiting |
| The Lundquist Institute at Harbor UCLA Medical Center | Torrance, California, United States | Recruiting |
| Memorialcare Long Beach Medical Center | Torrance, California, United States | Recruiting |
| HCA Florida - JFK Medical Center | Atlantis, Florida, United States | Recruiting |
| Boca Raton Regional Hospital Marcus Neuroscience Institute | Boca Raton, Florida, United States | Recruiting |
| Holy Cross Health | Fort Lauderdale, Florida, United States | Recruiting |
| University of Florida Jacksonville | Jacksonville, Florida, United States | Recruiting |
+ 54 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05065216