Condition: Type1diabetes · Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
To investigate in a prospective way changes in Mucosal-Associated Invariant T (MAIT) cells frequency, phenotype and function in link with the gut microbiota, gut integrity and the presence of Coxsackie virus B in two cohorts of pediatric patients: patients with a high genetic risk of type 1 diabetes and pediatric patients with recently diagnosed T1D by comparison with control subjects Tasks: 1. To measure blood MAIT cells frequency, phenotype and function in the three cohorts 2. To analyze gut microbiota and the presence of Coxsackie B enterovirus (CVB) and their impact on MAIT cell function 3. To evaluate gut integrity and analyze the gut mucosa 4. To integrate all the data obtained with T1D development and evolution
This description comes directly from the study's public registry record.
jacques beltrand, MD, PhD · +33144481545 · jacques.beltrand@aphp.fr
Always discuss trial participation with your own doctor first.
| Hopital privé d'Antony | Antony, France | Not Yet Recruiting |
| Hopital Necker enfants malades | Paris, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05054361