Condition: Glioblastoma Multiforme · Glioblastoma Multiforme, Adult · Supratentorial Glioblastoma · Sponsor: Leland Metheny
This phase II trial studies the effect of P140K MGMT hematopoietic stem cells, O6-benzylguanine, temozolomide, and carmustine in treating participants with supratentorial glioblastoma or gliosarcoma who have recently had surgery to remove most or all of the brain tumor (resected). Chemotherapy drugs, such as 6-benzylguanine, temozolomide, and carmustine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing. Placing P140K MGMT, a gene that has been created in the laboratory into bone marrow making the bone more resistant to chemotherapy, allowing intra-patient dose escalation which kills more tumor cells while allowing bone marrow to survive.
This description comes directly from the study's public registry record.
Melissa Bratley, RN · 1-800-641-2422 · CTUreferral@uhhospitals.org
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| University Hospitals Cleveland Medical Center | Cleveland, Ohio, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05052957