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Study identifier: NCT05037461 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Precision Radiotherapy Using MR-linac for Pancreatic Neuroendocrine Tumours in MEN1 Patients

Condition: Neuroendocrine Tumor of Pancreas · Multiple Endocrine Neoplasia Type 1  ·  Sponsor: J.M. de Laat

PhaseNA
Planned participants20
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Patients with the Multiple Endocrine Neoplasia type 1 (MEN1) syndrome are genetically predisposed for developping multiple pancreatic neuro-endocrine tumours (pNET). The management of small (pNET) in both MEN1 and sporadic cases, pose a major clinical challenge. At present, pancreatic surgery is the only curative treatment but it is associated with high morbidity. To reduce the morbidity ascosiated with surgery and thereby potentially improve quality of life for MEN1 patients introduction of less invasive techniques for treatment of pNET is important. High-dose-high precision MR-guided radiotherapy (MRgRT) holds promise as a new less invasive treatment option for pNET. The aim of this study is to assess efficiacy and safety of MRgRT for treatment of pNET in MEN1 patients.

This description comes directly from the study's public registry record.

Talk to the study team

Joanne M de Laat, Md, PhD  ·  +31302507397  ·  J.M.deLaat-4@umcutrecht.nl

Gerlof D Valk, MD, PhD  ·  +31302507397  ·  G.D.Valk@umcutrecht.nl

Always discuss trial participation with your own doctor first.

Locations (1)

UMC UtrechtUtrecht, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT05037461