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Study identifier: NCT05035745 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Selinexor & Talazoparib in Advanced Refractory Solid Tumors; Advanced/Metastatic Triple Negative Breast Cancer (START)

Condition: Advanced Refractory Solid Tumors · Advanced Triple Negative Breast Cancers · Metastatic Triple Negative Breast Cancers  ·  Sponsor: National University Hospital, Singapore

PhasePhase 1/Phase 2
Planned participants63
Who can joinAll sexes, 18 Years to 99 Years
Healthy volunteersNo

About this study

This is a single arm, open-label, phase I dose finding study, followed by a phase II expansion study. Phase I will be carried out in a modified 3+3 dose escalation design, with a projected enrolment of 33 patients with refractory solid tumors to determine the RP2D. In the phase II portion, a total of 30 patients with advanced/metastatic TNBC will be enrolled.

This description comes directly from the study's public registry record.

Talk to the study team

Soo Chin Lee  ·  6779 5555  ·  soo_chin_lee@nuhs.edu.sg

Always discuss trial participation with your own doctor first.

Locations (1)

National University HospitalSingapore, SingaporeRecruiting

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Source record: clinicaltrials.gov/study/NCT05035745