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Study identifier: NCT05035082 Synced from ClinicalTrials.gov · July 27, 2026
● Completed

A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE)

Condition: Diabetes Mellitus, Type 2  ·  Sponsor: Novo Nordisk A/S

PhasePhase 4
Planned participants1020
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is comparing the medicine RYBELSUS® to other medicines in people with type 2 diabetes who need extra treatment. All medicines used in this study are tablets which lower blood sugar in people with type 2 diabetes. The purpose of the study is to see how well RYBELSUS® is at lowering blood sugar compared to other tablets when used in addition to metformin. Participants doctor will give participants either RYBELSUS® or any other blood sugar lowering tablets - which treatment participants get is decided by chance. The doctor treating participants diabetes will give participants a prescription for the medicine and tell how to take it. The study will last for about 1 year. Participants will have 2 planned visits with their doctor which are part of the usual routine diabetes management: the first visit is when participants are included in the study, the second visit is a 1-year follow-up visit. In addition, the study personnel will contact participants up to 3 times during this period and to follow-up on information from participant doctors visits. Participant will be asked to respond 3 times to 4 questionnaires via their personal smartphone or tablet or paper if participant do not have access to one during the study. All clinic visits are part of the usual routine diabetes management and are covered by participants health insurance plan. The study team will collect information from these visits recorded in the medical chart. Women cannot take part if pregnant, breast-feed…

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (25)

Stewart Medical GroupAlhambra, California, United States
FDRCCosta Mesa, California, United States
Scripps Whittier Diabetes InstLa Jolla, California, United States
Raincross Medical GroupRiverside, California, United States
Reyes Clinical Research, IncMiami, Florida, United States
DC Research WorksMarietta, Georgia, United States
Urban Family Practice AssocMarietta, Georgia, United States
Macoupin Research GroupGillespie, Illinois, United States
UnityPoint Health-Diabetes Care CenterPeoria, Illinois, United States
Endeavor HealthSkokie, Illinois, United States
Kernodle Clin Dpt-Pvt DiagnostBurlington, North Carolina, United States
OnSite Clinical Solutions, LLC_CharlotteCharlotte, North Carolina, United States

+ 13 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05035082