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Study identifier: NCT05028062 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Naltrexone in AUD Reward Drinkers

Condition: Alcohol Use Disorder · Alcoholism  ·  Sponsor: University of Pennsylvania

PhasePhase 4
Planned participants60
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

This study is a phase IV, two-arm, randomized, double-blind, placebo-controlled study to assess whether individuals identified as primarily reward drinkers are significantly more likely to reduce heavy drinking if they receive XR-NTX than a matching placebo injection. Study subjects will receive monthly injections of long-acting injectable naltrexone 380 mg (4 mL) or matching placebo. All subjects will also receive 4 sessions of Medical Management (MM). Post-treatment follow-up visits will be conducted at 4 weeks after the scheduled completion of treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Timothy S Pond, MPH  ·  215-746-1959  ·  timpond@pennmedicine.upenn.edu

Rachel Weyl, BS  ·  215-746-1902  ·  rachel.weyl@pennmedicine.upenn.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Pennsylvania Center for Studies of AddictionPhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05028062