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Study identifier: NCT05027386 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Apatinib Mesylate Combined With IT Regimen for the Treatment of Recurrent or Refractory Pediatric Neuroblastoma: A Single-arm, Phase I/II,Multi-center, Clinical Study.

Condition: Neuroblastoma  ·  Sponsor: Sun Yat-sen University

PhasePhase 1/Phase 2
Planned participants125
Who can joinAll sexes, 5 Years to 18 Years
Healthy volunteersNo

About this study

The survival rate of recurrent and refractory pediatric neuroblastoma is low and the prognosis is poor. Apatinib mesylate is a highly selective small-molecule vasoendothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor. Apatinib mesylate has been shown to be safe and effective in recurrent or refractory pediatric neuroblastoma in Sun Yat-sen University Cancer Center. Apatinib mesylate combined with IT regimen is expected to further improve the efficacy and survival rate of recurrent or refractory pediatric neuroblastoma.

This description comes directly from the study's public registry record.

Talk to the study team

Yizhuo Zhang  ·  020-87342460  ·  zhangyzh@sysucc.org.cn

Always discuss trial participation with your own doctor first.

Locations (1)

Yizhuo ZhangGuangzhou, Guangdong, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT05027386