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Study identifier: NCT05025488 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm

Condition: Myelofibrosis · Essential Thrombocythemia · MPN  ·  Sponsor: Marina Kremyanskaya

PhasePhase 1
Planned participants10
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary objective of this study is to assess the safety and tolerability of administrating mutated-CALR peptide Vaccine to patients with MPN. The researchers plan to enroll 10 patients over a 12 month period. Maximum length of participation in 80 weeks. Patients will be asked to complete questionnaires, bone marrow biopsies, research lab collection, and standard of care lab draw. This research will be taking place only at The Mount Sinai Hospital, specifically at the Ruttenberg Treatment Center.

This description comes directly from the study's public registry record.

Talk to the study team

Marina Kremyanskaya, MD, PhD  ·  (212) 241-4106  ·  marina.kremyanskaya@mssm.edu

Gabriela Bello  ·  (212) 241-0463  ·  gabriela.bello@mssm.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Icahn School of Medicine at Mount SinaiNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05025488