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Study identifier: NCT05024097 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.

Condition: Rectal Cancer  ·  Sponsor: Weill Medical College of Cornell University

PhasePhase 2
Planned participants43
Who can joinAll sexes, 18 Years to 90 Years
Healthy volunteersNo

About this study

Enrolled patients will receive upfront (week 1) short-course radiotherapy to gross pelvic disease (25Gy in 5fx) in combination with AB928 (150 mg orally, once daily as part of a continuous dose regimen). This will be followed by consolidation chemotherapy (weeks 3-20) with mFOLFOX x9 cycles in combination with AB928 and AB122.

This description comes directly from the study's public registry record.

Talk to the study team

Fabiana Gregucci, M.D.  ·  646- 962-3110  ·  fgr4002@med.cornell.edu

Dakota Trick, M.S.  ·  646-962-2196  ·  dat4015@med.cornell.edu

Always discuss trial participation with your own doctor first.

Locations (3)

Weill Cornell Medical CollegeNew York, New York, United StatesRecruiting
Brooklyn Methodist Hospital - NewYork PresbyterianNew York, New York, United StatesRecruiting
New York Presbyterian Hospital - QueensNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05024097