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Study identifier: NCT05019703 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Atezolizumab and Cabozantinib for the Treatment of Adolescents and Young Adults With Recurrent or Metastatic Osteosarcoma, TACOS Study

Condition: Locally Advanced Osteosarcoma · Metastatic Osteosarcoma · Recurrent Osteosarcoma  ·  Sponsor: M.D. Anderson Cancer Center

PhasePhase 2
Planned participants40
Who can joinAll sexes, 12 Years to no upper limit
Healthy volunteersNo

About this study

This phase II trial studies the effect of atezolizumab and cabozantinib in treating adolescents and young adults with osteosarcoma that has come back (recurrent) or has spread to other places in the body (metastatic). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving atezolizumab and cabozantinib may help to control the osteosarcoma.

This description comes directly from the study's public registry record.

Talk to the study team

John A Livingston, MD  ·  (713) 792-3626  ·  jalivingston@mdanderson.org

Always discuss trial participation with your own doctor first.

Locations (2)

Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
M D Anderson Cancer CenterHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05019703