Condition: Critical Illness · Respiratory Failure · Sponsor: University of Turin, Italy
Tracheal intubation (TI) is associated with a high risk of adverse events in critically ill patients and peri-intubation hemodynamic collapse is the most commonly observed. The primary aim of the PREVENTION trial is to compare the effect of the pre-emptive use of noradrenaline versus no peri-intubation use of noradrenaline on incidence of cardiovascular collapse following TI in adult critically ill patients. Patients with absolute indication or contraindication to vasopressor support will be excluded from this trial. Patients will be randomized 1:1 to a continuous infusion of noradrenaline started before induction titrated according to baseline mean arterial pressure. The primary outcome will be the incidence of cardiovascular collapse. Secondary outcomes will include lowest systolic blood pressure and cardiac arrest within 30 minutes from intubation.
This description comes directly from the study's public registry record.
Vincenzo Russotto, MD · +393297893044 · vincenzo.russotto@unito.it
Antonella Vasamì · antonella.vasami@marionegri.it
Always discuss trial participation with your own doctor first.
| CHU de Nantes | Nantes, France | Not Yet Recruiting |
| Galway University Hospitals | Galway, Ireland | Not Yet Recruiting |
| Humanitas Research Hospital | Rozzano, Milan, Italy | Recruiting |
| University Hospital San Luigi Gonzaga | Orbassano, Turin, Italy | Not Yet Recruiting |
| ASST Grande Ospedale Metropolitano Niguarda | Milan, Italy | Recruiting |
| Policlinico di Milano | Milan, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05014581