Condition: Thyroid Eye Disease · Vasculitis · COPD Exacerbation Acute · Sponsor: Imperial College London
This is a pilot study to investigate serum prednisolone profiles in: * Patients on high doses of prednisolone for any inflammatory disorder, both in the acute and chronic setting. * Patients stepping up from or down to prednisolone therapy in association with a course of high dose methyl-prednisolone or dexamethasone. The study will comprise 3 groups, including those started on high doses of prednisolone acutely in an inpatient or outpatient setting, participants on chronically high doses, and those receiving a several week course of high dose methylprednisolone or dexamethasone. The study aims to measure prednisolone levels at a number of time points to investigate serum profile differences in those receiving prednisolone acutely compared with longer term steroid use. Further samples will be taken to characterise additional metabolic changes.
This description comes directly from the study's public registry record.
Katharine Lazarus, MBChB MRCP · 07555717544 · imperial.steroids@nhs.net
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| Imperial College Healthcare NHS Trust | London, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05012033