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Study identifier: NCT05011760 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

[C-11]NPA PET-amphetamine in Cocaine Use Disorders

Condition: Cocaine Use Disorder  ·  Sponsor: Rajesh Narendran

PhaseEARLY_Phase 1
Planned participants30
Who can joinAll sexes, 18 Years to 55 Years
Healthy volunteersNo

About this study

This study uses \[11C\]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD). Amphetamine-induced dopamine release data from this study will be correlated with \[11C\]NOP-1A VT measured at baseline in the midbrain. \[11C\]NOP-1A PET data will be used from aim 1 (see, Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)

This description comes directly from the study's public registry record.

Talk to the study team

Rajesh Narendran, MD  ·  4126475176  ·  narendranr@upmc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of PIttsburghPittsburgh, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05011760