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Study identifier: NCT05010005 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Ruxolitinib and Duvelisib in People With Lymphoma

Condition: T-cell Lymphomas · NK-Cell Lymphomas · T-cell Prolymphocytic Leukemia  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 1
Planned participants70
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will test the safety of ruxolitinib, given at one dose that does not change, and duvelisib, given at different doses, to find out what effects, if any, the study treatment has on people with relapsed or refractory NK-cell or T-cell lymphoma. This study has three parts: dose escalation (Part 1), dose expansion (Part 2), and TFH/T-PLL cohort expansion (Part 3).

This description comes directly from the study's public registry record.

Talk to the study team

Alison Moskowitz, MD  ·  646-608-3726  ·  moskowia@mskcc.org

Steven Horwitz, MD  ·  646-608-3725

Always discuss trial participation with your own doctor first.

Locations (9)

University of Miami (Data Collection Only)Miami, Florida, United StatesActive Not Recruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)Middletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen (Limited Protocol Activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Commack (Limited Protocol Activities)Commack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester (Limited Protocol Activities)Harrison, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
Memorial Sloan Kettering Nassau (Limited Protocol Activities)Uniondale, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05010005