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Study identifier: NCT05009927 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Efficiency of Imatinib Treatment After 10 Years of Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (Gist-Ten)

Condition: Metastatic Gastrointestinal Stromal Tumor (GIST) · C-KIT Mutation · Advanced Gastrointestinal Stromal Tumor (GIST)  ·  Sponsor: Centre Leon Berard

PhasePhase 2
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a 2 arms study concerning patients under imatinib treatment for at least 10 years of treatment with locally advanced/metastatic GIST. In the first arm, patients will discontinue Imatinib treatment. This arm will allow to determine if the re-introduction of Imatinib at relapse is still an efficient treatment for the control of disease. In the second arm, patients will continue Imatinib treatment, allowing to determine if the continuation of this treatment is efficient for disease control, by the rate of non-progression disease.

This description comes directly from the study's public registry record.

Talk to the study team

Jean-Yves BLAY, Pr  ·  +33 4 78 78 27 57  ·  jean-yves.blay@lyon.unicancer.fr

Always discuss trial participation with your own doctor first.

Locations (13)

CHU BesançonBesançon, FranceRecruiting
Institut BergoniéBordeaux, FranceRecruiting
CHU DupuytrenLimoges, FranceRecruiting
Centre Léon BérardLyon, FranceRecruiting
Institut Paoli CalmettesMarseille, FranceNot Yet Recruiting
Institut CurieParis, FranceNot Yet Recruiting
CHU de ReimsReims, FranceRecruiting
Centre Eugène MarquisRennes, FranceNot Yet Recruiting
Institut de Cancérologie de l'Ouest - Site Réné GauducheauSaint-Herblain, FranceNot Yet Recruiting
Institut de Cancérologie Lucien NEUWIRTHSaint-Paul-en-Jarez, FranceNot Yet Recruiting
Institut Claudius RegaudToulouse, FranceNot Yet Recruiting
Institut de Cancérologie de LorraineVandœuvre-lès-Nancy, FranceNot Yet Recruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05009927