Condition: Peritoneal Malignant Mesothelioma · Sponsor: National Cancer Institute (NCI)
This phase II trial compares the usual treatment alone (carboplatin, pemetrexed, and bevacizumab) to using immunotherapy (atezolizumab) plus the usual treatment in treating patients with peritoneal mesothelioma. The usual treatment consists of surgery or chemotherapy. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by stopping cells from using folic acid to make deoxyribonucleic acid and may kill cancer cells. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving atezolizumab with usual treatment may work better than usual treatment alone.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Mayo Clinic Hospital in Arizona | Phoenix, Arizona, United States | Suspended |
| Alliance for Clinical Trials in Oncology | Chicago, Illinois, United States | Recruiting |
| University of Chicago Comprehensive Cancer Center | Chicago, Illinois, United States | Recruiting |
| Carle at The Riverfront | Danville, Illinois, United States | Recruiting |
| Carle Physician Group-Effingham | Effingham, Illinois, United States | Recruiting |
| Carle Physician Group-Mattoon/Charleston | Mattoon, Illinois, United States | Recruiting |
| Carle Cancer Center | Urbana, Illinois, United States | Recruiting |
| The Carle Foundation Hospital | Urbana, Illinois, United States | Recruiting |
| University of Kentucky/Markey Cancer Center | Lexington, Kentucky, United States | Active Not Recruiting |
| Sanford Joe Lueken Cancer Center | Bemidji, Minnesota, United States | Recruiting |
| Mercy Hospital | Coon Rapids, Minnesota, United States | Recruiting |
| Fairview Southdale Hospital | Edina, Minnesota, United States | Recruiting |
+ 28 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05001880