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Study identifier: NCT04996875 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

Condition: Advanced Systemic Mastocytosis (AdvSM) · SM With an Associated Hematologic Neoplasm (SM-AHN) · Mast Cell Leukemia (MCL)  ·  Sponsor: Cogent Biosciences, Inc.

PhasePhase 2
Planned participants140
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is an open-label, two-part Phase 2 study investigating CGT9486 for the treatment of patients with Advanced Systemic Mastocytosis (AdvSM), including patients with Aggressive SM (ASM), SM with Associated Hematologic Neoplasm (SM-AHN), and Mast Cell Leukemia (MCL).

This description comes directly from the study's public registry record.

Talk to the study team

Cogent Biosciences, Inc.  ·  617-945-5576  ·  ApexInfo@cogentbio.com

Always discuss trial participation with your own doctor first.

Locations (42)

University of Alabama at Birmingham (UAB) HospitalBirmingham, Alabama, United StatesActive Not Recruiting
Mayo Clinic ArizonaPhoenix, Arizona, United StatesRecruiting
City of Hope Comprehensive Cancer CenterDuarte, California, United StatesRecruiting
UCLA Medical CenterLos Angeles, California, United StatesRecruiting
Stanford Cancer InstituteStanford, California, United StatesRecruiting
Galiz ResearchHialeah, Florida, United StatesWithdrawn
Winship Cancer Institute - Emory UniversityAtlanta, Georgia, United StatesRecruiting
Rush University Medical CenterChicago, Illinois, United StatesWithdrawn
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Columbia University Irving Medical CenterNew York, New York, United StatesWithdrawn
Cleveland Clinic Taussig Cancer CenterCleveland, Ohio, United StatesActive Not Recruiting
MUSC Health University Medical CenterCharleston, South Carolina, United StatesRecruiting

+ 30 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04996875