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Study identifier: NCT04992780 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Comparing Hypo-fractionated Intensity- Modulated Radiation Therapy to Standard- Fractionated IMRT Along With Chemotherapy and Immunotherapy for Non-Small Cell Lung Cancer

Condition: Non Small Cell Lung Cancer Stage  ·  Sponsor: University of Kansas Medical Center

PhasePhase 2
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The hypothesis for this study is that hypofractionated IMRT to 62.5 Gy in 25 fractions (2.5 Gy/fraction) with concurrent carboplatin and paclitaxel, followed by maintenance durvalumab will improve locoregional control at 18 months by 10% compared to standard-fractionated chemo-IMRT/durvalumab. A modest improvement in locoregional control (LRC) was selected as a target which could merit further study of this hypofractionated IMRT regimen in a Phase III trial

This description comes directly from the study's public registry record.

Talk to the study team

KUCC Navigation  ·  913-588-3671  ·  kucc_navigation@kumc.edu

Always discuss trial participation with your own doctor first.

Locations (6)

The University of Kansas Cancer Center, Westwood CampusKansas City, Kansas, United StatesRecruiting
The University of Kansas Cancer Center, Overland Park ClinicOverland Park, Kansas, United StatesRecruiting
KUCC MCA- TUKHS, Saint Francis HospitalTopeka, Kansas, United StatesNot Yet Recruiting
The University of Kansas Cancer Center, North ClinicKansas City, Missouri, United StatesRecruiting
The University of Kansas Cancer Center, Lee's Summit ClinicLee's Summit, Missouri, United StatesRecruiting
University of Kansas Cancer Center, North Kansas City HospitalNorth Kansas City, Missouri, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04992780