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Study identifier: NCT04991870 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Phase I CB-NK-TGF-ßR2-/NR3C1- in rGBM

Condition: Recurrent Gliosarcoma · Recurrent Supratentorial Glioblastoma · Supratentorial Gliosarcoma  ·  Sponsor: M.D. Anderson Cancer Center

PhasePhase 1
Planned participants25
Who can joinAll sexes, 12 Years to no upper limit
Healthy volunteersNo

About this study

This phase I trial is to find out the best dose, possible benefits and/or side effects of engineered natural killer (NK) cells containing deleted TGF-betaR2 and NR3C1 (cord blood \[CB\]-NK-TGF-betaR2-/NR3C1-) in treating patients with glioblastoma that has come back (recurrent). CB-NK-TGF-betaR2-/NR3C1- cells are genetically changed immune cells that may help to control the disease.

This description comes directly from the study's public registry record.

Talk to the study team

Shiao-Pei Weathers, MD  ·  713-792-2883  ·  sweathers@mdanderson.org

Always discuss trial participation with your own doctor first.

Locations (1)

M D Anderson Cancer CenterHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04991870