Condition: Child · Intensive Care Unit Acquired Weakness · Critical Illness · Sponsor: Johns Hopkins University
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments. Over half of critically ill children experience potentially preventable PICU-acquired morbidities, with mechanically ventilated children being at greatest risk. In critically ill adults, randomized trials have shown that progressive mobility, started early (within 3 days of initiating mechanical ventilation), decreases muscle weakness and the duration of mechanical ventilation. However, similar randomized studies have not been conducted in the PICU. The investigator's prior studies revealed that less than 10 percent of critically ill children at the highest risk of functional decline are evaluated by a physical or occupational therapist within 3 days of PICU admission. Given the interplay of sedation, delirium, sleep, and immobility in the PICU, single-component interventions, such as sedation protocolization, have not consistently shown benefit for decreasing mechanical ventilation duration. Thus, the investigators developed the first pediatric-specific, interprofessional intervention (PICU Up!) to integrate goal-directed sedation, delirium prevention, sleep promotion, and family engagement into daily PICU care in order to facilitate early and progressive mobility. The investigators have demonstrated the safety and feasibility of this pragmatic, multifaceted strategy in both single-site and multicent…
This description comes directly from the study's public registry record.
Sapna R Kudchadkar, MD, PhD · 410-955-6412 · sapna@jhmi.edu
Colleen Mennie, RN · 410-955-6412 · cmennie1@jhmi.edu
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| Valley Children's Hospital | Madera, California, United States | Recruiting |
| Nemours Children's Hospital of the Nemours Foundation | Orlando, Florida, United States | Recruiting |
| Norton Children's Hospital: University of Louisville | Louisville, Kentucky, United States | Recruiting |
| Johns Hopkins Hospital | Baltimore, Maryland, United States | Active Not Recruiting |
| Hennepin Healthcare: University of Minnesota | Minneapolis, Minnesota, United States | Recruiting |
| Children's Hospital at Dartmouth: Geisel School of Medicine | Lebanon, New Hampshire, United States | Recruiting |
| UNC Children's: University of North Carolina | Chapel Hill, North Carolina, United States | Recruiting |
| Janet Weis Children's Hospital: Geisinger Commonwealth School of Medicine | Danville, Pennsylvania, United States | Recruiting |
| Texas Children's Hospital: Baylor College of Medicine | Houston, Texas, United States | Recruiting |
| West Virginia University Medicine Children's: West Virginia University | Morgantown, West Virginia, United States | Recruiting |
| Children's Hospital of Wisconsin: Medical College of Wisconsin | Milwaukee, Wisconsin, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04989790